Tag Archives: experimental

Isotretinoin treatment for acne does not induce insulin resistance

over a 3-month period, show study findings published in the journal Clinical and Experimental Dermatology. (Source: MedWire News - Dermatology)
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Family History of Alcoholism, Smoking, and Subjective Responses to Alcohol: Reply to Poikolainen (2010)

(Source: Alcoholism: Clinical and Experimental Research) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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Acupuncture Inhibits GABA Neuron Activity in the Ventral Tegmental Area and Reduces Ethanol Self-Administration.

Conclusions:  These findings suggest that DOR-mediated opioid modulation of VTA GABA neurons may mediate acupuncture's role in modulating mesolimbic DA release and suppressing the reinforcing effects of ethanol. PMID: 20860620 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and receive $5 free advertising.
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Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites.

Conclusions:  These data demonstrate that a disease with an autoimmune-like pathophysiology can be generated in this animal model using soluble MAA-modified syngeneic liver cytosols as the immunogen. These studies provide insight into potential mechanism(s) that the metabolites of alcohol may play in contributing to the onset of an autoimmune-like disease in patients with alcoholic liver disease.
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Ethanol-Induced Conditioned Taste Aversion in Male Sprague-Dawley Rats: Impact of Age and Stress.

Conclusions:  Together, these experiments demonstrate an adolescent-specific insensitivity to the aversive properties of ethanol that elicit CTA, a pattern not influenced by repeated restraint stress or housing in social isolation. This age-related insensitivity to the dysphoric effects of ethanol is consistent with other work from our laboratory, adding further to the evidence that adolescent rats are less susceptible to negative consequences of ethanol that may serve as cues to curb consumption.
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Cognitive Performance in Treatment-Naïve Active Alcoholics.

Conclusions:  Our results extend findings that TNAD show minimal behavioral effects of chronic heavy alcohol use and are consistent with the contention that TNAD are relatively cognitively intact.
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Implications of ER Stress, the Unfolded Protein Response, and Pro- and Anti-Apoptotic Protein Fingerprints in Human Monocyte-Derived Dendritic Cells…

Conclusion:  Results of these analyses provide insights into alcohol mechanisms of regulating DC and suggest that alcohol induced specifically the UPR in DC. We speculate that activation of a UPR by alcohol may protect the DC from oxidant injury but may lead to the development of alcohol-related diseases
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Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking.

Conclusions:  These results suggest that during adolescence, individuals that are insensitive to aversive effects are most likely to develop problem drinking behaviors. These results underscore the importance of the interaction between developmental stage and individual variation in sensitivity to alcohol.
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Increase in Alcohol Intake, Reduced Flexibility of Alcohol Drinking, and Evidence of Signs of Alcohol Intoxication in Sardinian Alcohol-Preferring…

Conclusions:  These data suggest that the "Wise" procedure is effective in inducing marked increases in alcohol intake in sP rats.
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